HELPING THE OTHERS REALIZE THE ADVANTAGES OF LIGAZ FOOTBALL

DNA ligases seal five′-PO4 and 3′-OH polynucleotide finishes via 3 nucleotidyl transfer techniques involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are vital guardians of genomic integrity, and ligase dysfunction underlies human genetic ailment syndromes. Crystal structures of DNA ligases bound to nucleotide and nucleic a